About Lifetime Risk

Lifetime Risk Pooling Project

Although the Framingham Risk Score (FRS) represents an important advance in the primary prevention of cardiovascular disease, it has well-recognized limitations. For example, the FRS classifies most younger individuals and virtually all women as low-risk in spite of significant differences in risk factor burden, reflecting the importance of age in the 10-year risk equation. In response, European guidelines as well as national guidelines from the National Cholesterol Education Program and the American Heart Association suggest physicians consider current risk factor burden within the context of long-term or lifetime risk for cardiovascular disease.

Long-term risk estimates provide novel information regarding risk prediction that is not obtained through modifications of the 10-year risk window. In collaboration with investigators at Northwestern University, we have pooled individual-level data from participants in multiple, unique observational cohorts to create the Cardiovascular Lifetime Risk Pooling Project. Our objective is to determine the lifetime risks for cardiovascular disease death, fatal/non-fatal coronary heart disease, and fatal/non-fatal stroke for risk factors measured at four index ages: age 45-, 55-, 65-, and 75-years. We believe that these findings could be useful for practicing clinicians to identify novel groups of individuals for more intensive lifestyle or pharmacologic preventive interventions.

The Team



Jarett D. Berry, M.D., M.S.

Dr. Jarett D. Berry

Jarett D. Berry, M.D., M.S.

Internal Medicine – Cardiology

UT Southwestern Medical School

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